College
Buchtel College of Arts and Sciences
Date of Last Revision
2023-05-04 20:30:03
Major
Biomedical Science
Honors Course
3100: 499
Number of Credits
3
Degree Name
Bachelor of Science
Date of Expected Graduation
Summer 2021
Abstract
Titanium Dioxide (TiO2, titania) nanoparticles are widely studied in cosmetology, food administration, and medical fields. This is due to the nanoparticles’ suitable properties, specific combination of strength and high corrosion resistance. With the increasing attention to these particles, there is concern with potential health complications. Some of the complications involved with titania nanoparticles include blood clots and immune reactions (Sit et al., 2019). In this study, we continue the study conducted in the Sahai research group (J. Chen. MS thesis, 2020), on the binding of titania nanoparticles with blood plasma proteins, focusing on potential effects of shape only. Hydrophobicity of the titania nanoparticles of three different shapes (nanotubes, nanorods, and rutile hexagonal nanotubes) was established by heating the nanotube and nanorod samples. This was done to ensure that the samples had similar hydrophobic properties. The protein adsorption isotherms showed little adsorption to these samples due to their high hydrophobic properties. Subsequently, nanotubes and anatase hexagonal nanoparticles were tested because the two samples have similar hydrophilic properties but different shapes. The protein adsorption isotherms for these two samples showed similar binding affinities for the fibrinogen protein, however, the human serum albumin protein adsorbed poorly and did not yield accurate results.
Research Sponsor
Dr. Nita Sahai
First Reader
Dr. Richard Londraville
Second Reader
Dr. Rolando Ramirez
Honors Faculty Advisor
Dr. Brian Bagatto
Recommended Citation
Miller, Morgan, "Titanium Dioxide Nanoparticles Binding to Human Blood Plasma Proteins" (2021). Williams Honors College, Honors Research Projects. 1361.
https://ideaexchange.uakron.edu/honors_research_projects/1361