Date of Last Revision

2019-05-06 12:54:54

Major

Biology

Degree Name

Bachelor of Science

Date of Expected Graduation

Spring 2019

Abstract

Bisphenol F (BPF) is an analog compound of the xenoestrogen bisphenol A (BPA). BPA utilization has decreased dramatically due to its detrimental effects as an endocrine disrupter. In place of BPA, BPF is growing to be a ubiquitous chemical in epoxy resin manufacturing. Recent research has begun to investigate the possible endocrinal effects of BPF as an analog of BPA. This study was performed to examine the potential effects of BPF exposure on cardiac parameters of zebrafish (Danio rerio) embryos. Embryos were exposed to 50 µg/L BPF for 48 hours, and cardiac parameters (stroke volume, heart rate, and cardiac output) were determined at 24- and 48-hours post-exposure through video microscopy and motion analysis. Stroke volume and cardiac output of embryos decreased significantly with a reduction of 40% in the first 24 hours but returned to a non-significant difference from control embryos at 48 hours post-exposure.

Research Sponsor

Dr. Brian Bagatto

First Reader

Dr. Richard Londraville

Second Reader

Dr. Rolando Ramirez

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