Date of Last Revision
2023-05-03 13:00:37
Major
Biology
Degree Name
Bachelor of Science
Date of Expected Graduation
Spring 2019
Abstract
Bisphenol F (BPF) is an analog compound of the xenoestrogen bisphenol A (BPA). BPA utilization has decreased dramatically due to its detrimental effects as an endocrine disrupter. In place of BPA, BPF is growing to be a ubiquitous chemical in epoxy resin manufacturing. Recent research has begun to investigate the possible endocrinal effects of BPF as an analog of BPA. This study was performed to examine the potential effects of BPF exposure on cardiac parameters of zebrafish (Danio rerio) embryos. Embryos were exposed to 50 µg/L BPF for 48 hours, and cardiac parameters (stroke volume, heart rate, and cardiac output) were determined at 24- and 48-hours post-exposure through video microscopy and motion analysis. Stroke volume and cardiac output of embryos decreased significantly with a reduction of 40% in the first 24 hours but returned to a non-significant difference from control embryos at 48 hours post-exposure.
Research Sponsor
Dr. Brian Bagatto
First Reader
Dr. Richard Londraville
Second Reader
Dr. Rolando Ramirez
Recommended Citation
Monnot, Kyle, "The Effects of Bisphenol F on Embryonic Cardiac Output in Zebrafish" (2019). Williams Honors College, Honors Research Projects. 968.
https://ideaexchange.uakron.edu/honors_research_projects/968
Included in
Comparative and Evolutionary Physiology Commons, Developmental Biology Commons, Other Pharmacology, Toxicology and Environmental Health Commons