Date of Last Revision
2023-05-03 05:11:39
Major
Biology
Degree Name
Bachelor of Science
Date of Expected Graduation
Spring 2018
Abstract
The goal of the research is to investigate the structural changes seen in Primary Congenital Glaucoma using a mouse model. Eye sections of a Cyp1b1-/- mouse were compared to eye sections of a healthy normal mouse (wild type, WT). Initial examination of the cornea, iris, and irodocorneal angle showed structural changes in Cyp1b1-/-. These changes were similar to those described in the literature using other animal models. This suggests that a mutation in Cyp1b1-/- in a mouse results in a phenotype similar to that seen in PCG human patients and this model could be used to investigate the pathophysiology of PCG.
Research Sponsor
Rachida Bouhenni
First Reader
Dr. Jordan Renna
Second Reader
Luis Prozena
Recommended Citation
Barto, Kylie, "ANALYSIS OF OCULAR CHANGES IN A CYP1B1-/- MOUSE" (2018). Williams Honors College, Honors Research Projects. 745.
https://ideaexchange.uakron.edu/honors_research_projects/745