Buchtel College of Arts and Sciences

Date of Last Revision

2024-01-17 07:06:15


Biomedical Science

Honors Course

BIOL 499

Number of Credits


Degree Name

Bachelor of Science

Date of Expected Graduation

Winter 2023


This experiment will aim to explore the heterodimerization of Dopamine (D2) and Adenosine (A2A) receptors in cells when bound to different ligands. Borroto-Escuela et al. (2018) investigated the dimerization of the A2AR-D2R in rats when administered with cocaine, and they found that disrupting the A2AR-D2R complex restores the cocaine reward system in rats. This was a strong influence as to why we chose to investigate A2AR-D2R dimerization in Chinese hamster ovary (CHO) cells.

One goal that we have for this experiment is to combine our current laboratory skills with new laboratory techniques. There are constantly new techniques in labs, and performing this research project will allow us to have the confidence in our base skills to know that we can carry out new techniques properly.

Our main motivation in performing this research project is to learn from our PhD student. Working with Grant, we will explore the dimerization of D2R and A2AR. As Grant publishes his own paper about GPCR, we will highlight our contributions made at the undergraduate level. If successful, we will play a role in preparing cells that will be imaged to explore the dimerization.

Research Sponsor

Dr. Richard Londraville

First Reader

Dr. Jordan Renna

Second Reader

Dr. Rachel Olson

Honors Faculty Advisor

Dr. Brian Bagatto

Proprietary and/or Confidential Information




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