College
Buchtel College of Arts and Sciences
Date of Last Revision
2024-01-17 07:06:15
Major
Biomedical Science
Honors Course
BIOL 499
Number of Credits
2
Degree Name
Bachelor of Science
Date of Expected Graduation
Winter 2023
Abstract
This experiment will aim to explore the heterodimerization of Dopamine (D2) and Adenosine (A2A) receptors in cells when bound to different ligands. Borroto-Escuela et al. (2018) investigated the dimerization of the A2AR-D2R in rats when administered with cocaine, and they found that disrupting the A2AR-D2R complex restores the cocaine reward system in rats. This was a strong influence as to why we chose to investigate A2AR-D2R dimerization in Chinese hamster ovary (CHO) cells.
One goal that we have for this experiment is to combine our current laboratory skills with new laboratory techniques. There are constantly new techniques in labs, and performing this research project will allow us to have the confidence in our base skills to know that we can carry out new techniques properly.
Our main motivation in performing this research project is to learn from our PhD student. Working with Grant, we will explore the dimerization of D2R and A2AR. As Grant publishes his own paper about GPCR, we will highlight our contributions made at the undergraduate level. If successful, we will play a role in preparing cells that will be imaged to explore the dimerization.
Research Sponsor
Dr. Richard Londraville
First Reader
Dr. Jordan Renna
Second Reader
Dr. Rachel Olson
Honors Faculty Advisor
Dr. Brian Bagatto
Proprietary and/or Confidential Information
No
Recommended Citation
Vukovic, Elena and Macatol, Jackson M., "Dimerization of Dopamine (D2) and Adenosine (A2A) Receptors" (2023). Williams Honors College, Honors Research Projects. 1761.
https://ideaexchange.uakron.edu/honors_research_projects/1761