College
Buchtel College of Arts and Sciences
Date of Last Revision
2023-05-08 17:26:51
Major
Biomedical Science
Honors Course
Honors Research Project
Number of Credits
2
Degree Name
Bachelor of Science
Date of Expected Graduation
Spring 2023
Abstract
Preeclampsia is a complication of pregnancy, where the placenta lacks sufficient blood flow due to abnormal formation of the vascular endothelial cells. This results in hypertension and increased reactive oxygen species, causing oxidative stress. The VEGF (vascular endothelial growth factor) helps develop new growth, so by increasing the receptors VEGFR2 by injection of LTP nanoparticles into the uterine wall of RUPP rats, one can see if there would be improvement in the otherwise reduced uterine pressure pregnant rat. This would be confirmed by the 8-isoprostane test, which measures oxidative stress.
Research Sponsor
Dr. Rolando JJ Ramirez
First Reader
Dr. Henry Astley
Second Reader
Dr. M Rumman Hossain
Honors Faculty Advisor
Dr. Brian Bagatto
Proprietary and/or Confidential Information
No
Recommended Citation
Ganios, Sophia, "Reducing Placental Oxidative Stress in a Rat Model Preeclampsia Using VEGFR2 Nanoparticles" (2023). Williams Honors College, Honors Research Projects. 1724.
https://ideaexchange.uakron.edu/honors_research_projects/1724