College
Buchtel College of Arts and Sciences
Date of Last Revision
2023-05-05 15:32:10
Major
Biology
Honors Course
Biology
Number of Credits
2
Degree Name
Bachelor of Science
Date of Expected Graduation
Spring 2022
Abstract
This project will use chemogenetic drug activation in the inferior colliculus (IC) to formulate a new tinnitus model in animals. Gq-signaling DREADD [AAV8-CaMIIKa-HDM2(Gq)-mCherry] will be used to selectively activate glutamatergic neurons in the mouse, then the brain will be dissected to obtain the IC. The IC will be immunohistochemically stained to visualize the AAV mCherry, the glutamatergic neuron distribution, and the GABAergic neuron distribution within the IC. Thus, the findings of this study will better our understandings of the pathological mechanisms of tinnitus.
Research Sponsor
Dr. Jianxin Bao
First Reader
Dr. Joseph Pinkl
Second Reader
McKenzie Rice
Honors Faculty Advisor
Dr. Brian Bagatto
Proprietary and/or Confidential Information
Yes
Recommended Citation
Bunner, Cara, "Chemogenetic Induced Tinnitus Model" (2022). Williams Honors College, Honors Research Projects. 1593.
https://ideaexchange.uakron.edu/honors_research_projects/1593
Complete Project Summary
Bunner Honors Sig Page.pdf (164 kB)