College

Buchtel College of Arts and Sciences

Date of Last Revision

2021-04-25 16:06:18

Major

Chemistry

Honors Course

3150:497

Number of Credits

2

Degree Name

Bachelor of Science

Date of Expected Graduation

Spring 2021

Abstract

This project aims to analyze the effect that the chain length of oligo0glutamic acid sequences has on the nucleation, growth, and phase transformation of amorphous calcium phosphate to crystalline hydroxyapatite. As cited in the formal proposal, hydroxyapatite is the main mineral in bone and dentin and it is of particular interest as a biomaterial. Mineralization is required for much of its structural and protective functioning, however the timing of mineralization is also important for proper growth and development. The presence of glutamic acid containing protein residues impacts the mineralization patterns of hydroxyapatite and this study aims to determine exactly what effect the specific chain length has on this process.

Research Sponsor

Dr. Nita Sahai

First Reader

Dr. Sailaja Paruchuri

Second Reader

Dr. Putu Ustriyana

Honors Faculty Advisor

Dr. Adam Smith

Comments

This project focuses on determining the effect that the nature of peptide sequences has on the biomineralization process of hydroxyapatite.

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