College
Buchtel College of Arts and Sciences
Date of Last Revision
2023-05-04 07:38:51
Major
Chemistry
Honors Course
3150:497
Number of Credits
2
Degree Name
Bachelor of Science
Date of Expected Graduation
Spring 2021
Abstract
This project aims to analyze the effect that the chain length of oligo0glutamic acid sequences has on the nucleation, growth, and phase transformation of amorphous calcium phosphate to crystalline hydroxyapatite. As cited in the formal proposal, hydroxyapatite is the main mineral in bone and dentin and it is of particular interest as a biomaterial. Mineralization is required for much of its structural and protective functioning, however the timing of mineralization is also important for proper growth and development. The presence of glutamic acid containing protein residues impacts the mineralization patterns of hydroxyapatite and this study aims to determine exactly what effect the specific chain length has on this process.
Research Sponsor
Dr. Nita Sahai
First Reader
Dr. Sailaja Paruchuri
Second Reader
Dr. Putu Ustriyana
Honors Faculty Advisor
Dr. Adam Smith
Recommended Citation
Harmon, Emma, "An Investigation on the Effect of the Chain Length of Glutamic Acid Oligomers on the Nucleation, Precipitate Growth, and Phase Transformation of Amorphous Calcium Phosphate to Crystalline Hydroxyapatite" (2021). Williams Honors College, Honors Research Projects. 1272.
https://ideaexchange.uakron.edu/honors_research_projects/1272
Signature Page
Comments
This project focuses on determining the effect that the nature of peptide sequences has on the biomineralization process of hydroxyapatite.