College

Buchtel College of Arts and Sciences

Date of Last Revision

2020-12-30 11:32:06

Major

Biology

Honors Course

Senior Honors Project in Biology

Number of Credits

3

Degree Name

Bachelor of Science

Date of Expected Graduation

Fall 2020

Abstract

Glaucoma is a build-up of pressure in the eye that leads to the gradual loss of sight. The intention of this study was to investigate how glaucoma affects intrinsically photosensitive Retinal Ganglion Cells (ipRGCs). These cells contain melanopsin, a photopigment, that enables the cells to react to light. Four-month-old control and five-month-old glaucoma mice retinas were dissected, stained using primary and secondary antibodies, then traced using ImageJ’s Simple Neurite Tracer. There were no significant differences in soma size, total dendritic length, dendritic field size, and dendritic field diameter between control and glaucoma ipRGCs. However, further research is needed to provide conclusive evidence regarding glaucoma’s effects on retinal cells.

Research Sponsor

Dr. Jordan Renna

First Reader

Dr. Qin Liu

Second Reader

Dr. Richard Londraville

Honors Faculty Advisor

Dr. Brian Bagatto

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