College
Buchtel College of Arts and Sciences
Date of Last Revision
2023-05-04 12:19:21
Major
Biology
Honors Course
Senior Honors Project in Biology
Number of Credits
3
Degree Name
Bachelor of Science
Date of Expected Graduation
Fall 2020
Abstract
Glaucoma is a build-up of pressure in the eye that leads to the gradual loss of sight. The intention of this study was to investigate how glaucoma affects intrinsically photosensitive Retinal Ganglion Cells (ipRGCs). These cells contain melanopsin, a photopigment, that enables the cells to react to light. Four-month-old control and five-month-old glaucoma mice retinas were dissected, stained using primary and secondary antibodies, then traced using ImageJ’s Simple Neurite Tracer. There were no significant differences in soma size, total dendritic length, dendritic field size, and dendritic field diameter between control and glaucoma ipRGCs. However, further research is needed to provide conclusive evidence regarding glaucoma’s effects on retinal cells.
Research Sponsor
Dr. Jordan Renna
First Reader
Dr. Qin Liu
Second Reader
Dr. Richard Londraville
Honors Faculty Advisor
Dr. Brian Bagatto
Recommended Citation
Cook, Samantha, "Investigating the morphology of ipRGCs in control vs. glaucomatous retinas" (2020). Williams Honors College, Honors Research Projects. 1249.
https://ideaexchange.uakron.edu/honors_research_projects/1249