Major

Biology

Degree Name

Bachelor of Science

Date of Graduation

Spring 2019

Abstract

This is the final write-up for an honors research project for the University of Akron Williams Honors College. Synthesis of novel imidazolium salts was conducted. Following synthesis of imidazolium salts, the stability of the compound was tested at 37°C over a 72-hour period to give preliminary information about drug stability in vivo. 2D NMR was also conducted to confirm the structure of TPP-1. The student wrote an experimental protocol for the use of C57BL/6 mice and performed the online CITI training by the IRB to prepare to work with animals in a study of the antitumor properties of imidazolium salts in mice. Plausible physiological mechanisms by which the imidazolium cations exert their anti-tumor effects are discussed; current evidence demonstrates that imidazolium cations may be targeting the mitochondria of cancer cells.

Research Sponsor

Dr. Wiley Youngs

First Reader

Dr. Sailaja Paruchuri

Second Reader

Dr. Aliaksei Boika

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