Title of Proposal
Chemical Engineering - Cooperative Education
Bachelor of Science
Date of Graduation
The main objective of this honor’s project is to encapsulate drugs with different molecular weights inside of chitosan-heparin based nanoparticles (Cs-Hep NPs). Three different drugs with low (NNC), medium (IFN-γ), and large (BSA) molecular weights were chosen in order to compare all types of drugs and how they react with the nanoparticles. Analysis of particle size, zeta potential, and a release study was performed. The release took place over a 168-hour time period and liquid samples were taken throughout. The hypothesis was that the molecular weight of the drug will correlate to the physical properties of the nanoparticles. The results of the particle size analysis show that the largest particle size was determined to be interferon gamma (IFN-γ, ~2500nm), NNC-042090 (NNC, ~450nm), Nanoparticles (~350nm), and bovine serum albumin (BSA, ~50nm). The results of the zeta potential show that the encapsulated particles have a higher electro potential than empty nanoparticles. NNC released 80% of the encapsulated drug, BSA released 70% of the encapsulated drug, while IFN-γ only released about 50% of the encapsulated drug. Therefore, judging from these results, the hypothesis partially holds true for all drugs.
Dr. Nic Leipzig
Dr. Roya Gitiafroz
Dr. Bi-min Newby
Richwine, Trent, "Synthesis of Drug Encapsulated Chitosan-Heparin Based Nanoparticles and Release Study" (2019). Williams Honors College, Honors Research Projects. 879.