College of Engineering and Polymer Science

Date of Last Revision

2023-05-06 09:11:04


Chemical Engineering

Honors Course

CHEE 497

Number of Credits


Degree Name

Bachelor of Science

Date of Expected Graduation

Spring 2023


Amyloid beta (Aβ) is considered a major component in the progression of degenerative disease like Alzheimer’s disease. In an attempt to cure Alzheimer’s before it has presented, this project proposes a study on the effects of protegrin-1 (PG-1) on the aggregation of Aβ. By cross-seeding to form a PG-1- Aβ heterocomplex, it is believed that aggregation of Aβ on the human brain can be inhibited, thus helping to stop the neurodegeneration caused by Alzheimer’s disease. To complete this project, an initial literature review of previous work done by the graduate student leading the project will be completed. After this, experiments will be conducted on PG-1-Aβ heterocomplexes. These experiments will include a variety of spectroscopy and microscopy, showing the extent of which they have cross-seeded. By performing these tests, it is possible to view the structure of the heterocomplex as well as if Aβ aggregation was inhibited as desired. The final step of the project will be testing on bacterial and cell assays. While lab experiments are useful, it is best to analyze how different structures perform in a biological environment. By using bacterial and cell assays, the effect of PG-1-Aβ heterocomplexes on the biological aggregation of Aβ can be analyzed.

Research Sponsor

Jie Zheng

First Reader

Bi-min Zhang Newby

Second Reader

Brian Bagatto

Honors Faculty Advisor

Zhenmeng Peng

Proprietary and/or Confidential Information




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