College
College of Engineering and Polymer Science
Date of Last Revision
2023-05-06 09:11:04
Major
Chemical Engineering
Honors Course
CHEE 497
Number of Credits
3
Degree Name
Bachelor of Science
Date of Expected Graduation
Spring 2023
Abstract
Amyloid beta (Aβ) is considered a major component in the progression of degenerative disease like Alzheimer’s disease. In an attempt to cure Alzheimer’s before it has presented, this project proposes a study on the effects of protegrin-1 (PG-1) on the aggregation of Aβ. By cross-seeding to form a PG-1- Aβ heterocomplex, it is believed that aggregation of Aβ on the human brain can be inhibited, thus helping to stop the neurodegeneration caused by Alzheimer’s disease. To complete this project, an initial literature review of previous work done by the graduate student leading the project will be completed. After this, experiments will be conducted on PG-1-Aβ heterocomplexes. These experiments will include a variety of spectroscopy and microscopy, showing the extent of which they have cross-seeded. By performing these tests, it is possible to view the structure of the heterocomplex as well as if Aβ aggregation was inhibited as desired. The final step of the project will be testing on bacterial and cell assays. While lab experiments are useful, it is best to analyze how different structures perform in a biological environment. By using bacterial and cell assays, the effect of PG-1-Aβ heterocomplexes on the biological aggregation of Aβ can be analyzed.
Research Sponsor
Jie Zheng
First Reader
Bi-min Zhang Newby
Second Reader
Brian Bagatto
Honors Faculty Advisor
Zhenmeng Peng
Proprietary and/or Confidential Information
No
Recommended Citation
Robinson, Sarah, "Cross-seeding of Protegin-1 and Amyloid Beta to inhibit Amyloid Beta aggregation" (2023). Williams Honors College, Honors Research Projects. 1661.
https://ideaexchange.uakron.edu/honors_research_projects/1661