College
Buchtel College of Arts and Sciences
Date of Last Revision
2023-05-06 08:07:43
Major
Biochemistry
Honors Course
CHEM_497_001_4427
Number of Credits
4
Degree Name
Bachelor of Science
Date of Expected Graduation
Spring 2023
Abstract
Studies have shown that HERs are involved in the progression of human cancers. Researchers have found that HER2 mutations in colorectal cancer are similar to mutations found in breast cancer. Recombinant antibodies are effective therapeutic treatments for cancers. Antibodies can also be used to determine how proteins function under normal and pathophysiological conditions while also identifying interacting partners. In this Honors Project, my aim is to investigate the effect of an oncogenic mutant of HER2. Considering the information above, the question researched in this project was: how does the S310F mutation affect the organization and function of HER2? The specific goal of this research project is to determine the effect of the HER2 mutation on EGFR activity. My approach for this project is to carry out a phosphorylation assay of EGFR in the presence of HER2 wild-type (WT) and the HER2 mutant S310F. The results of this project will be able to build off of past HER-2 research in efforts of applying it to cancer research.
Research Sponsor
Dr. Aliaksei Boika
First Reader
Dr. Chris Wesdemiotis
Second Reader
Dr. Yi Pang
Honors Faculty Advisor
Dr. William Donovan
Proprietary and/or Confidential Information
No
Recommended Citation
Kalik, Paige, "Effect of an Oncogenic HER2 Mutant on EGFR Activity" (2023). Williams Honors College, Honors Research Projects. 1648.
https://ideaexchange.uakron.edu/honors_research_projects/1648
Comments
Keywords: HER2, EGFR, cancer, phosphorylation assay, antibody, fluorescence