College

Buchtel College of Arts and Sciences

Date of Last Revision

2021-05-06 15:14:55

Major

Biology

Honors Course

3100:499:003

Number of Credits

3

Degree Name

Bachelor of Science

Date of Expected Graduation

Spring 2021

Abstract

In recent times, Nanoparticles (NPs) are used in medical practices especially for their contribution to drug delivery. Blood plasma protein binds to titanium dioxide nanoparticles and prevent the delivery of drugs to the intended target. When the protein binds to the NPs, the NPs in turn change the secondary structure of the blood plasma protein. This can affect drug delivery and thrombosis. The different shapes of these NPs influence the binding affinity and adsorption of the blood plasma protein. The research analyzed the NPs for two variables, shape and hydrophobicity. We conducted this experiment to further research effects of hydrophobicity and hydrophilicity of the NPs on the binding properties of the blood plasma protein. Fg had a higher binding affinity than HSA to the NPs. HSA failed to adsorb on any of the nanoparticles. Anatase had a higher binding affinity than the sample of NTs. These results indicate hydrophilicity and hydrophobicity does have an effect on protein adsorption. Further research could give us insight on the differences in secondary structure between NPs of different shapes and different levels of hydrophobicity or hydrophilicity.

Research Sponsor

Dr. Nita Sahai

First Reader

Dr. Rolando J. J. Ramirez

Second Reader

Dr. Richard Londraville

Honors Faculty Advisor

Dr. Brian Bagatto

Signature Page TZ (236 kB)
Final Submission Signature Page

Included in

Biology Commons

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.