College

Buchtel College of Arts and Sciences

Date of Last Revision

2021-05-06 08:55:26

Major

Biomedical Science

Honors Course

3100-499-002

Number of Credits

2

Degree Name

Bachelor of Science

Date of Expected Graduation

Spring 2021

Abstract

Preeclampsia is a pregnancy complication that is characterized mainly by hypertension in the mother. The exact pathogenesis of preeclampsia is unknown, although the disease is attributed to a number of factors such as angiogenic factor levels and endothelial dysfunction. Presently, the control program for the disease involves the delivery of the fetus and the placenta. There is a need to develop novel therapies that would control preeclampsia from the moment it is diagnosed to minimize the effects on the mother and child. VEGF is a protein involved in the pathogenesis of the condition. The defect in one of its receptors, VEGFR2, brings forwards many of the detrimental effects in preeclampsia such as endothelial dysfunction and prevention of vasodilation. This review paper summarizes ten studies over the recent years to illustrate where the current research is headed towards and what therapies are at work at the moment. Risk factors, mRNA expression, protein expression, biomarkers, current therapies, related diseases, and single polypeptide nucleotides of VEGF/VEGFR2 pathway in reference to preeclampsia are looked at to draw a pattern of commonalities and differences in this review as well.

Research Sponsor

Rolando J.J. Ramirez

First Reader

Qin Liu

Second Reader

Janna Andronowski

Honors Faculty Advisor

Brian Bagatto

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