Title
Strong Resistance of Phosphorylcholine Self-assembled Monolayers to Protein Adsorption: Insights into Nonfouling Properties of Zwitterionic Materials
Document Type
Article
Publication Date
Fall 2005
Abstract
In this work, we show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMs) to protein adsorption and examine key factors leading to their nonfouling behavior using both experimental and molecular simulation techniques. Zwitterions with a balanced charge and minimized dipole are excellent candidates as nonfouling materials due to their strong hydration capacity via electrostatic interactions.
Volume
127
Issue
41
First Page
14473
Last Page
14478
Recommended Citation
Liu, Lingyan and Zheng, Jie, "Strong Resistance of Phosphorylcholine Self-assembled Monolayers to Protein Adsorption: Insights into Nonfouling Properties of Zwitterionic Materials" (2005). Chemical, Biomolecular, and Corrosion Engineering Faculty Research. 227.
https://ideaexchange.uakron.edu/chemengin_ideas/227