Title
Nanoparticles for Drug Delivery Prepared from Amphiphilic Plga Zwitterionic Block Copolymers with Sharp Contrast in Polarity Between Two Blocks
Document Type
Article
Publication Date
Spring 2010
Abstract
In sharp contrast: Poly(carboxybetaine) (PCB)–poly(lactic-co-glycolic acid) (PLGA) block copolymers were obtained by inclusion of tBu groups onto the PCB monomers. The resulting self-assembled PLGA core/PCB shell nanoparticles have extraordinary stability and a high potential for functionalization because of the COO− groups on the PCB shell (see picture; EDC=1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; NHS=N-hydroxysuccinimide).
Volume
122
First Page
3859
Last Page
3864
Recommended Citation
Cheng, Gang, "Nanoparticles for Drug Delivery Prepared from Amphiphilic Plga Zwitterionic Block Copolymers with Sharp Contrast in Polarity Between Two Blocks" (2010). Chemical, Biomolecular, and Corrosion Engineering Faculty Research. 149.
https://ideaexchange.uakron.edu/chemengin_ideas/149