Polymer Science Faculty Research

Title

Drug Eluting Electrospun Rubbery Fiber Mats

Document Type

Conference Proceeding

Publication Date

Spring 3-16-2014

Abstract

This work reports release studies of acetylsalicylic acid (Aspirin), a model drug from electrospun ArbomatrixTM {a block copolymer with arborescent polyisobutylene (PIB) core and poly (para-methyl styrene) PMS end blocks} polymer fiber mats. ArbomatrixTM –PEG polymer solutions containing 15 and 30 wt% Aspirin were electrospun onto parchment paper to yield free-standing rubbery fiber mats. Aspirin release into phosphate buffered saline (PBS) solution (pH = 7.4) at 37oC was measured by UV spectroscopy. In three days 42 and 90% of the loaded Aspirin was released from the mats containing 15 and 30wt% Aspirin, respectively. Due to the excellent biocompatibility of ArbomatrixTM these mats hold great promise for drug delivery applications.

Publication Title

Abstracts of Papers of the American Chemical Society

Volume

247

Issue

301-pmse