Date of Graduation

Winter 2017

Document Type

Honors Research Project

Degree Name

Bachelor of Science


Chemistry - Biochemistry

Research Sponsor

Leah Shriver

First Reader

Adam Smith

Second Reader

Christopher Ziegler


Disturbances of iron metabolism caused by bleeding may directly impact neuronal function. As in Alzheimer patients, much of the neurodegeneration is due to oxidative stress in the brain caused by the break down of hemin.The same oxidative stress is present with the degradation of hematin in CSF. When hematin is degraded in the cytosol of the cell, it causes the release of Fe2+which is then oxidized into Fe3+. The oxidation of the iron produces the radical hydroxyl groups, which damages proteins and DNA. The disruption of these molecules result in subsequent apoptosis in neuronal cells.