Identification of a Highly Specific Hydroxyapatite-binding Peptide using Phage Display
A peptide sequence SVSVGMKPSPRP that selectively recognizes hydroxyapatite (HA) is identified by using a phage display approach. The engineered sequence exhibits chemical and structural specificity for HA over calcium carbonate and HA's amorphous calcium phosphate precursor. In situ binding to HA in a tooth cross section further demonstrates the sequence specificity and utility in nondestructive imaging applications.
Roy, Marc D.; Stanley, Scott K.; Amis, Eric J.; and Becker, Matthew, "Identification of a Highly Specific Hydroxyapatite-binding Peptide using Phage Display" (2008). Polymer Science Faculty Research. 171.