Strain-Promoted Crosslinking of PEG-based Hydrogels via Copper-Free Cycloaddition
The synthesis of a 4-dibenzocyclooctynol (DIBO) functionalized poly(ethylene glycol) (PEG) and fabrication of hydrogels via strain-promoted, metal-free, azide–alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative to encapsulate cells that are sensitive to photochemical or chemical cross-linking mechanisms.
ACS Macro Letters
Zheng, Jukan; Smith Callahan, Laura A.; Hao, Jinkun; Guo, Kai; Wesdemiotis, Chrys; Weiss, Robert; and Becker, Matthew L., "Strain-Promoted Crosslinking of PEG-based Hydrogels via Copper-Free Cycloaddition" (2012). Polymer Engineering Faculty Research. 1941.