Polymer Science Faculty Research

Title

Formulation and photoirradiation parameters that influenced photoresponsive drug delivery using alkoxylphenacyl-based polycarbonates

Document Type

Article

Publication Date

Fall 11-2014

Abstract

Recently, we reported the synthesis and biocompatibility of alkoxylphenacyl-based polycarbonates (APP); a promising new class of polymers that undergo photo-induced chain scission. In the current study, nanoparticles (NPs) were prepared from the APP Polymer (APP-NPs) and loaded with doxorubicin (DOX) (DOX-APP-NPs) in order to identify and evaluate formulation and photoirradiation parameters that influence photoresponsive efficacy. Stable and spherical APP-NPs were prepared with diameters between 70-80 nm depending on APP concentration (10-40 mg/mL). There was a direct relationship between APP concentration and resultant particle size. Drug release studies indicated that exposure to the phototrigger was capable of altering the rate and extent of DOX released. Photoresponsive DOX release was markedly influenced by the frequency of photoirradiation while the effect of APP concentration was most likely propagated through NP size. DOX released by photoactivation retained its efficacy as assessed by cytotoxicity studies in human lung adenocarcinoma (A549) cells. Studies in BALB/c mice indicated that DOX-APP-NPs induce less cardiotoxicity than DOX alone and that DOX-APP-NPs are not susceptible to dose dumping after photoirradiation. (C) 2014 Elsevier B.V. All rights reserved.

Publication Title

European Journal of Pharmaceutics and Biopharmaceutics

Volume

88

Issue

3

First Page

962

Last Page

972