Date of Graduation

Spring 2018

Document Type

Honors Research Project

Degree Name

Bachelor of Science



Research Sponsor

Rachida Bouhenni

First Reader

Dr. Jordan Renna

Second Reader

Luis Prozena


The goal of the research is to investigate the structural changes seen in Primary Congenital Glaucoma using a mouse model. Eye sections of a Cyp1b1-/- mouse were compared to eye sections of a healthy normal mouse (wild type, WT). Initial examination of the cornea, iris, and irodocorneal angle showed structural changes in Cyp1b1-/-. These changes were similar to those described in the literature using other animal models. This suggests that a mutation in Cyp1b1-/- in a mouse results in a phenotype similar to that seen in PCG human patients and this model could be used to investigate the pathophysiology of PCG.

Included in

Eye Diseases Commons