Title of Proposal
Bachelor of Science
Date of Graduation
The goal of the research is to investigate the structural changes seen in Primary Congenital Glaucoma using a mouse model. Eye sections of a Cyp1b1-/- mouse were compared to eye sections of a healthy normal mouse (wild type, WT). Initial examination of the cornea, iris, and irodocorneal angle showed structural changes in Cyp1b1-/-. These changes were similar to those described in the literature using other animal models. This suggests that a mutation in Cyp1b1-/- in a mouse results in a phenotype similar to that seen in PCG human patients and this model could be used to investigate the pathophysiology of PCG.
Dr. Jordan Renna
Barto, Kylie, "ANALYSIS OF OCULAR CHANGES IN A CYP1B1-/- MOUSE" (2018). Williams Honors College, Honors Research Projects. 745.