Date of Last Revision
2023-05-03 05:07:53
Major
Chemistry - Biochemistry
Degree Name
Bachelor of Science
Date of Expected Graduation
Summer 2018
Abstract
G protein coupled receptors (GPCRs) are membrane proteins with many functional roles. This family of receptors is expansive, with several subfamilies. Here, a member of subfamily A, rhodopsin (Rho) is studied. Mutations in rhodopsin have been linked to the disease retinitis pigmentosa (RP). Some of these mutations have been found to disrupt the dimerization/oligomerization of Rho at the TM4/TM5 proposed dimerization interface, causing pathogenesis of RP. In this study, two mutations of transmembrane helix 5 were investigated for changes in dimerization and stability, cell trafficking, and signaling. It was found that the V209M and F220C mutations did not result in disruption of dimerization of Rho.
Research Sponsor
Adam W. Smith
First Reader
Sailaja Paruchuri
Second Reader
Leah Shriver
Recommended Citation
Pinkevitch, Margaret, "Mutations in Rhodopsin Transmembrane Helix 5 and Dimerization Interface" (2018). Williams Honors College, Honors Research Projects. 693.
https://ideaexchange.uakron.edu/honors_research_projects/693