Chemistry - Biochemistry
Bachelor of Science
Date of Expected Graduation
Disturbances of iron metabolism caused by bleeding may directly impact neuronal function. As in Alzheimer patients, much of the neurodegeneration is due to oxidative stress in the brain caused by the break down of hemin.The same oxidative stress is present with the degradation of hematin in CSF. When hematin is degraded in the cytosol of the cell, it causes the release of Fe2+which is then oxidized into Fe3+. The oxidation of the iron produces the radical hydroxyl groups, which damages proteins and DNA. The disruption of these molecules result in subsequent apoptosis in neuronal cells.
Oates, Dominique, "Determination of Metabolic Change Associated with Subarachnoid Hemorrhage" (2017). Williams Honors College, Honors Research Projects. 599.