Major

Chemistry - Biochemistry

Degree Name

Bachelor of Science

Date of Expected Graduation

Winter 2017

Abstract

Disturbances of iron metabolism caused by bleeding may directly impact neuronal function. As in Alzheimer patients, much of the neurodegeneration is due to oxidative stress in the brain caused by the break down of hemin.The same oxidative stress is present with the degradation of hematin in CSF. When hematin is degraded in the cytosol of the cell, it causes the release of Fe2+which is then oxidized into Fe3+. The oxidation of the iron produces the radical hydroxyl groups, which damages proteins and DNA. The disruption of these molecules result in subsequent apoptosis in neuronal cells.

Research Sponsor

Leah Shriver

First Reader

Adam Smith

Second Reader

Christopher Ziegler

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.