Date of Last Revision
2023-05-02 23:40:59
Major
Chemistry - Biochemistry
Degree Name
Bachelor of Science
Date of Expected Graduation
Spring 2017
Abstract
Drug delivery to the central nervous system is complicated by the blood-brain barrier, a vascular structure that prevents free diffusion of molecules into brain tissue. In this study, we examined the in vitro properties of a nanoparticle-based drug delivery system. We used several nanoparticle formulations, both LTP based and PLGA based, to test the cellular uptake and toxicity in microglial cells. Using immunofluorescence imaging, we show that LTP nanoparticles are taken up by microglia. We confirmed that our nanoparticle formulations are non-toxic by two cell viability assays. These results suggest that nanoparticle formulations may be a biocompatible method of delivering drugs to the brain.
Research Sponsor
Dr. Leah Shriver
First Reader
Dr. Sailaja Paruchuri
Second Reader
Dr. Adam Smith
Recommended Citation
Baker, Emily, "Nanoparticle Targeting to the Central Nervous System" (2017). Williams Honors College, Honors Research Projects. 486.
https://ideaexchange.uakron.edu/honors_research_projects/486