Date of Last Revision
2023-05-02 23:41:00
Major
Chemistry - Biochemistry
Degree Name
Bachelor of Science
Date of Expected Graduation
Spring 2017
Abstract
Preeclampsia is a hypertensive disease of pregnant women that is known to cause detrimental physiological complications to both the mother and fetus. The hypertension hypothesized to result from endothelial dysfunction may be improved therapeutically by increasing Vascular Endothelial Growth Factor ligand concentration and it’s Vascular Endothelial Growth Factor Receptor 2 (VEGF and VEGFR2). Together, this receptor pathway may help overall vasodilation of key blood vessels linking the mother and fetal placental unit, allowing for increased clinical pathologies of both. Previous studies have also linked increased reactive oxygen species (ROS) production in preeclamptic pregnancies to the damaged endothelial tissues of the placenta. This specific investigation will use RUPP model to measure the effect of increased VEGF and VEGFR2 expression on ROS production in placental tissues, measured using lucigenin-enhanced chemiluminescence (LECL). These results may help further characterize ROS role in hypertensive pregnancies physiological demise, and help indicate whether VEGFR may serve as a potential therapeutic in treating preeclampsia.
Research Sponsor
Dr. Rolando J. J. Ramirez
First Reader
Dr. Leah Shriver
Second Reader
Dr. Jordan Renna
Recommended Citation
Gindlesberger, Abigail J., "The Potential Role of Oxidative Stress in Reduced Uterine Perfusion Pressure Vascular Reactivity" (2017). Williams Honors College, Honors Research Projects. 485.
https://ideaexchange.uakron.edu/honors_research_projects/485