College

Buchtel College of Arts and Sciences

Date of Last Revision

2025-01-14 08:41:26

Major

Biomedical Science

Honors Course

BIOL 499

Number of Credits

2

Degree Name

Bachelor of Science

Date of Expected Graduation

Winter 2024

Abstract

In 2023, Ohio legalized recreational cannabis use for adults over 21; however, research on the physiological effectsof cannabis-derived compounds, particularly cannabidiol (CBD), remains limited due to i ts narcotics classification.While CBD is known to antagonize Cannabinoid Receptor 1 (CB1), a receptor found in the cardiac tissue of a numberof organisms, the effects on cardiac activity are not fully understood. This study aimed to investigate the impact ofCBD on heart rate in Daphnia magna. The hypothesis posited that CBD would increase heart rate in Daphnia byantagonizing CB1 receptors or equivalent G-protein-coupled receptors. The subjects were exposed to threetreatments: control (dechlorinated water), 2% ethanol, and a 0.6 mM CBD solution in 2% ethanol. Results showed nosignificant difference between the control and ethanol groups, but the CBD group exhibited a significant decrease inheart rate compared to the control. These findings suggest a complex interaction between CBD , ethanol, and thecardiac system in Daphnia magna, warranting further investigation in order to establish Daphnia magna as a modelorganism for the study of CBD effects.

Research Sponsor

Dr. Brian Bagatto

First Reader

Dr. Rachel Olson

Second Reader

Richard Londraville

Honors Faculty Advisor

Brian Bagatto

Proprietary and/or Confidential Information

No

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.