College
Buchtel College of Arts and Sciences
Date of Last Revision
2025-01-14 08:41:26
Major
Biomedical Science
Honors Course
BIOL 499
Number of Credits
2
Degree Name
Bachelor of Science
Date of Expected Graduation
Winter 2024
Abstract
In 2023, Ohio legalized recreational cannabis use for adults over 21; however, research on the physiological effectsof cannabis-derived compounds, particularly cannabidiol (CBD), remains limited due to i ts narcotics classification.While CBD is known to antagonize Cannabinoid Receptor 1 (CB1), a receptor found in the cardiac tissue of a numberof organisms, the effects on cardiac activity are not fully understood. This study aimed to investigate the impact ofCBD on heart rate in Daphnia magna. The hypothesis posited that CBD would increase heart rate in Daphnia byantagonizing CB1 receptors or equivalent G-protein-coupled receptors. The subjects were exposed to threetreatments: control (dechlorinated water), 2% ethanol, and a 0.6 mM CBD solution in 2% ethanol. Results showed nosignificant difference between the control and ethanol groups, but the CBD group exhibited a significant decrease inheart rate compared to the control. These findings suggest a complex interaction between CBD , ethanol, and thecardiac system in Daphnia magna, warranting further investigation in order to establish Daphnia magna as a modelorganism for the study of CBD effects.
Research Sponsor
Dr. Brian Bagatto
First Reader
Dr. Rachel Olson
Second Reader
Richard Londraville
Honors Faculty Advisor
Brian Bagatto
Proprietary and/or Confidential Information
No
Recommended Citation
Ross, Joanna, "Impact of Cannabidol (CBD) on Daphnia magna Heart Rate" (2024). Williams Honors College, Honors Research Projects. 1912.
https://ideaexchange.uakron.edu/honors_research_projects/1912