Reducing Placental Oxidative Stress in a Rat Model Preeclampsia Using VEGFR2 Nanoparticles
Buchtel College of Arts and Sciences
Date of Last Revision
Honors Research Project
Number of Credits
Bachelor of Science
Date of Expected Graduation
Preeclampsia is a complication of pregnancy, where the placenta lacks sufficient blood flow due to abnormal formation of the vascular endothelial cells. This results in hypertension and increased reactive oxygen species, causing oxidative stress. The VEGF (vascular endothelial growth factor) helps develop new growth, so by increasing the receptors VEGFR2 by injection of LTP nanoparticles into the uterine wall of RUPP rats, one can see if there would be improvement in the otherwise reduced uterine pressure pregnant rat. This would be confirmed by the 8-isoprostane test, which measures oxidative stress.
Dr. Rolando JJ Ramirez
Dr. Henry Astley
Dr. M Rumman Hossain
Honors Faculty Advisor
Dr. Brian Bagatto
Proprietary and/or Confidential Information
Ganios, Sophia, "Reducing Placental Oxidative Stress in a Rat Model Preeclampsia Using VEGFR2 Nanoparticles" (2023). Williams Honors College, Honors Research Projects. 1724.