College

Buchtel College of Arts and Sciences

Date of Last Revision

2022-05-16 04:37:07

Major

Biomedical Science

Honors Course

3100:499

Number of Credits

3

Degree Name

Bachelor of Science

Date of Expected Graduation

Spring 2022

Abstract

Within the mammalian retina, there are melanopsin-containing ganglion cells. These intrinsically photoreceptive cells help control behavioral aspects of vision as well as to aid in circadian rhythms. In this project, it will be determined whether or not glaucoma has an effect on these cells, and what that effect is, from different points in the disease. Glaucoma is an eye disease that damages the retinal ganglion cells and eventually causes them to die, also it can be linked to irregular circadian rhythm. Many techniques will be used to prepare this project but computer imaging will be the primary method for determining the effect glaucoma has on these cells. Computer imaging will be used to to trace neurons in control and experimental mice retinal ganglion cells. In addition to tracing, the method will be used to measure soma size of the neuron, the sum of its dendritic lengths, the dendritic field size, and the diameter of the dendritic field, in both groups in order to then run statistical data analysis and compare the results to see if glaucoma truly does have a significant effect on melanopsin retinal ganglion cells in mice.

Research Sponsor

Jordan Renna

First Reader

Rolando Juan Jose Ramirez

Second Reader

Robert Joel Duff

Honors Faculty Advisor

Jordan Renna

Proprietary and/or Confidential Information

No

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