Buchtel College of Arts and Sciences
Date of Last Revision
Number of Credits
Bachelor of Science
Date of Expected Graduation
Within the mammalian retina, there are melanopsin-containing ganglion cells. These intrinsically photoreceptive cells help control behavioral aspects of vision as well as to aid in circadian rhythms. In this project, it will be determined whether or not glaucoma has an effect on these cells, and what that effect is, from different points in the disease. Glaucoma is an eye disease that damages the retinal ganglion cells and eventually causes them to die, also it can be linked to irregular circadian rhythm. Many techniques will be used to prepare this project but computer imaging will be the primary method for determining the effect glaucoma has on these cells. Computer imaging will be used to to trace neurons in control and experimental mice retinal ganglion cells. In addition to tracing, the method will be used to measure soma size of the neuron, the sum of its dendritic lengths, the dendritic field size, and the diameter of the dendritic field, in both groups in order to then run statistical data analysis and compare the results to see if glaucoma truly does have a significant effect on melanopsin retinal ganglion cells in mice.
Rolando Juan Jose Ramirez
Robert Joel Duff
Honors Faculty Advisor
Proprietary and/or Confidential Information
McMullen, Abigail, "Effect of Glaucoma on Melanopsin Retinal Ganglion Cells in Mice" (2022). Williams Honors College, Honors Research Projects. 1610.