College

Buchtel College of Arts and Sciences

Date of Last Revision

2022-05-11 08:48:12

Major

Biology

Honors Course

Biology

Number of Credits

2

Degree Name

Bachelor of Science

Date of Expected Graduation

Spring 2022

Abstract

This project will use chemogenetic drug activation in the inferior colliculus (IC) to formulate a new tinnitus model in animals. Gq-signaling DREADD [AAV8-CaMIIKa-HDM2(Gq)-mCherry] will be used to selectively activate glutamatergic neurons in the mouse, then the brain will be dissected to obtain the IC. The IC will be immunohistochemically stained to visualize the AAV mCherry, the glutamatergic neuron distribution, and the GABAergic neuron distribution within the IC. Thus, the findings of this study will better our understandings of the pathological mechanisms of tinnitus.

Research Sponsor

Dr. Jianxin Bao

First Reader

Dr. Joseph Pinkl

Second Reader

McKenzie Rice

Honors Faculty Advisor

Dr. Brian Bagatto

Proprietary and/or Confidential Information

Yes

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