Buchtel College of Arts and Sciences
Date of Last Revision
Number of Credits
Bachelor of Science
Date of Expected Graduation
This project will use chemogenetic drug activation in the inferior colliculus (IC) to formulate a new tinnitus model in animals. Gq-signaling DREADD [AAV8-CaMIIKa-HDM2(Gq)-mCherry] will be used to selectively activate glutamatergic neurons in the mouse, then the brain will be dissected to obtain the IC. The IC will be immunohistochemically stained to visualize the AAV mCherry, the glutamatergic neuron distribution, and the GABAergic neuron distribution within the IC. Thus, the findings of this study will better our understandings of the pathological mechanisms of tinnitus.
Dr. Jianxin Bao
Dr. Joseph Pinkl
Honors Faculty Advisor
Dr. Brian Bagatto
Proprietary and/or Confidential Information
Bunner, Cara, "Chemogenetic Induced Tinnitus Model" (2022). Williams Honors College, Honors Research Projects. 1593.