College

Buchtel College of Arts and Sciences

Date of Last Revision

2021-12-08 18:04:46

Major

Biology

Honors Course

3100:499-003

Number of Credits

3

Degree Name

Bachelor of Science

Date of Expected Graduation

Fall 2021

Abstract

Tinnitus is a serious neurological condition effecting 10-15% of adults, and can lead to other symptoms such as difficulty concentrating and sleeping, anxiety, and depression. Currently there are no FDA approved drugs to prevent or treat tinnitus, mainly due to a lack of understanding of its cellular and molecular pathways. T- and L- type calcium channels have been implicated in the modulation of tinnitus, as well as the dysfunction of gamma-aminobutyric acid (GABA) neurons. This study used the sound-based avoidance detection (SBAD) method in order to detect tinnitus and determine whether pharmacological treatments had an effect in mediating tinnitus. T-type calcium channel blockers were found to be ineffective in treating tinnitus, while L-type calcium channel blockers lead to significant improvements. The mechanism of action in using L-type calcium channel blockers was not fully understood and could be attributed to other molecular targets. Further research will focus on other molecular targets, in order to determine how tinnitus can be treated.

Research Sponsor

Jianxin Bao

First Reader

Joey Pinkl

Second Reader

John Hawks

Honors Faculty Advisor

Brian Bagatto

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