College of Engineering and Polymer Science

Date of Last Revision

2021-09-14 07:59:11


Chemical Engineering

Honors Course


Number of Credits


Degree Name

Bachelor of Science

Date of Expected Graduation

Spring 2021


This project addressed burn wound healing through controlled release of the antibacterial drug mafenide encapsulated by a copolyster into 3D printed scaffolds. Scaffolds were printed at 25oC and 0.77-1 bar in a cross-hatch pattern with uniform thickness, distance between parallel layers, and diameter then photo-crosslinked. The number of scaffolds available for testing was limited by the amount of polymer that could be synthesized. A high-performance liquid chromatography method was developed specifically for this experiment and used to determine daily release of mafenide from the scaffold into a 2-mL phosphate buffer solution. During the first 24 hours a large burst release of 299.9 mg or 7.9% of the initial drug amount was observed for the 2-layer scaffolds and 403.1 mg or 8.7% of its initial drug amount for the 3-layer scaffolds. Within 120 hours, the release rate had dropped to less than 100 mg per day for both scaffold types. The cumulative average release for the 2-layer and 3-layer scaffolds was determined to be 1449.0 mg (38.8% of the initial total) and 1469.5 mg (31.8% of the initial total) respectively. The results suggest that these scaffolds have the potential to become a viable treatment option in the future.

Research Sponsor

Abraham Joy

First Reader

Roya Gitiafroz

Second Reader

Bi-min Zhang Newby

Honors Faculty Advisor

Bi-min Zhang Newby



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