Polymer Science Faculty Research

Title

Radiopaque, Iodine Functionalized, Phenylalanine-Based Poly(ester urea)s

Document Type

Article

Publication Date

Winter 1-9-2015

Abstract

The synthesis and characterization of iodine-functionalized phenylalanine-based poly(ester urea)s (PEUs) are reported. 4-Iodo-l-phenylalanine and l-phenylalanine were separately reacted with 1,6-hexanediol to produce two monomers, bis-4-I-l-phenylalanine-1,6-hexanediol-diester (1-IPHE-6 monomer) and bis-l-phenylalanine-1,6-hexanediol-diester (1-PHE-6 monomer). By varying the feed ratio of the 1-IPHE-6 and 1-PHE-6 monomers, the copolymer composition was modulated resulting in a wide variation in thermal, mechanical and radiopacity properties. Microcomputed tomography (μ-CT) projections demonstrate that increasing iodine content results in greater X-ray contrast. Compression tests of dry and wet porous scaffolds indicate that the poly(1-IPHE-6)0.24-co-poly(1-PHE-6)0.76 material results in the highest compression modulus. MC3T3 cell viability and spreading studies show PEUs are nontoxic to cells. As most medical device procedures require placement verification via fluoroscopic imaging, materials that possess inherent X-ray contrast are valuable for a number of applications.

Publication Title

Biomacromolecules

Volume

16

Issue

2

First Page

615

Last Page

624