Polymer Science Faculty Research
Title
Cell Permeable Nanoconjugates of Shell-Crosslinked Knedel (SCK) and Peptide Nucleic Acids (PNAs) with Uniquely Expressed or Over-Expressed mRNA Targeting Sequences for Early Diagnosis and Therapy of Cancer
Document Type
Patent
Publication Date
7-20-2006
Abstract
A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2′-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
Recommended Citation
Becker, Matthew; Fang, Huafeng; Li, Xiaoxu; Pan, Dipanjan; Rossin, Raffaella; Sun, Xiankai; Taylor, John-Stephen; Turner, Jeffery; Welch, Michael; and Wooley, Karen, "Cell Permeable Nanoconjugates of Shell-Crosslinked Knedel (SCK) and Peptide Nucleic Acids (PNAs) with Uniquely Expressed or Over-Expressed mRNA Targeting Sequences for Early Diagnosis and Therapy of Cancer" (2006). Polymer Science Faculty Research. 179.
https://ideaexchange.uakron.edu/polymerscience_ideas/179