Polymer Science Faculty Research

Title

Identification of a Highly Specific Hydroxyapatite-binding Peptide using Phage Display

Document Type

Article

Publication Date

5-15-2008

Abstract

A peptide sequence SVSVGMKPSPRP that selectively recognizes hydroxyapatite (HA) is identified by using a phage display approach. The engineered sequence exhibits chemical and structural specificity for HA over calcium carbonate and HA's amorphous calcium phosphate precursor. In situ binding to HA in a tooth cross section further demonstrates the sequence specificity and utility in nondestructive imaging applications.

Publication Title

Advanced Materials

Volume

20

Issue

10

First Page

1830

Last Page

1836