Mechanical Engineering Faculty Research

Title

Abstract A1: Impact of CYP2D6*10 and CYP3A5*3 Polymorphisms on the Pharmacokinetics of Tamoxifen in Asian Breast Cancer Patients

Document Type

Article

Publication Date

4-1-2010

Abstract

Tamoxifen (TAM) is a selective estrogen receptor modulator employed in the treatment of breast cancer. It is a prodrug with a complex metabolic pathway involving several phase I and II metabolic enzymes. TAM is metabolized by cytochrome P450 (CYP) enzymes to N-desmethyltamoxifen (NDM), 4-hydroxytamoxifen (4OHT) and endoxifen (END) with 4OHT and END being the active metabolites of TAM. CYP2D6 and CYP3A4/5 comprises the major CYP isoforms mediating the metabolism of TAM although other CYP isoforms also play a role. Polymorphisms present in genes encoding these CYP enzymes may influence the metabolism and pharmacokinetics of TAM and its metabolites.

Publication Title

Clinical Cancer Research

Volume

16

Issue

7

First Page

A1