Mechanical Engineering Faculty Research

Title

Patterning Surfaces for Controlled Platelet Adhesion and Detection of Dysfunctional Platelets

Document Type

Article

Publication Date

4-18-2013

Abstract

Platelets play a fundamental role in thrombus formation and in the pathogenesis of arterial thrombosis. Patterning surfaces for controlled platelet adhesion paves the way for adhesion and activation mechanisms in platelets and detection of platelet functional defects. Here, a new and simple method based on controlled polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) on the surface of styrene-block-(ethylene-co-butylene)-block-styrene (SEBS) is shown. The competition between polymerization and degradation enables platelet adhesion on SEBS to be switched on and off. The adhesive sites of the platelets can be down to single cell level, and the dysfunctional platelets can be quantitatively detected.

Publication Title

Macromolecular Bioscience

Volume

13

Issue

6

First Page

676

Last Page

681