Date of Graduation
Honors Research Project
Bachelor of Science
Dr. Jordan Renna
The goal of the research is to investigate the structural changes seen in Primary Congenital Glaucoma using a mouse model. Eye sections of a Cyp1b1-/- mouse were compared to eye sections of a healthy normal mouse (wild type, WT). Initial examination of the cornea, iris, and irodocorneal angle showed structural changes in Cyp1b1-/-. These changes were similar to those described in the literature using other animal models. This suggests that a mutation in Cyp1b1-/- in a mouse results in a phenotype similar to that seen in PCG human patients and this model could be used to investigate the pathophysiology of PCG.
Barto, Kylie, "ANALYSIS OF OCULAR CHANGES IN A CYP1B1-/- MOUSE" (2018). Honors Research Projects. 745.