Date of Graduation

Spring 2015

Document Type

Honors Research Project

Degree Name

Bachelor of Science

Major

Chemistry

Research Sponsor

Dr. Wiley J. Youngs

First Reader

Dr. Michael Konopka

Second Reader

Dr. Matthew J. Panzner

Abstract

A series of N,N’-bis(arylmethyl)benzimidazolium salts with hydrophilic and lipophilic substituents have been synthesized, characterized, and tested against select non-small cell cancer cell lines. Substituent variations on the imidazole ring have shown that lipophilicity and hydrophilicity can influence the imidazolium salts’ anti-proliferative activity and aqueous solubility.

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