Determination of Metabolic Change Associated with Subarachnoid Hemorrhage

Author

Dominique OatesFollow

Date of Last Revision

2023-05-03 03:42:55

Major

Chemistry - Biochemistry

Degree Name

Bachelor of Science

Date of Expected Graduation

Winter 2017

Abstract

Disturbances of iron metabolism caused by bleeding may directly impact neuronal function. As in Alzheimer patients, much of the neurodegeneration is due to oxidative stress in the brain caused by the break down of hemin.The same oxidative stress is present with the degradation of hematin in CSF. When hematin is degraded in the cytosol of the cell, it causes the release of Fe²⁺which is then oxidized into Fe³⁺. The oxidation of the iron produces the radical hydroxyl groups, which damages proteins and DNA. The disruption of these molecules result in subsequent apoptosis in neuronal cells.

Research Sponsor

Leah Shriver

First Reader

Adam Smith

Second Reader

Christopher Ziegler

Recommended Citation

Oates, Dominique, "Determination of Metabolic Change Associated with Subarachnoid Hemorrhage" (2017). Williams Honors College, Honors Research Projects. 599.
https://ideaexchange.uakron.edu/honors_research_projects/599