Date of Last Revision
2023-05-03 00:58:30
Major
Chemistry - Biochemistry
Degree Name
Bachelor of Science
Date of Expected Graduation
Summer 2017
Abstract
Chiari Malformation Type I is a neurodegenerative trait that can result from disease or from acquiring. Metabolomic analysis was done on normal pressure hydrocephalous and Chiari CSF samples using LC-MS and multiple bioinformatic programs. After analysis from multiple programs, we were able to analyze the stringency in statistical algorithms done by each program and determined qualities that are shared between programs that offer multiple details. We identified dysregulation in glucuronated metabolites in CSF of Chiari versus NPH. Using LC-MS, we established the experimental MS/MS of glucuronic acid in attempt to identify similarities in mass-to-charge features primarily identified. We could not positively identify glucuronic acid dysregulation in Chiari, yet established putatively dysregulated metabolic pathways.
Research Sponsor
Dr. Leah Shriver
First Reader
Dr. Adam Smith
Second Reader
Dr. Claire Tessier
Recommended Citation
Korsmo, Hunter W., "Metabolomic Profiling of Chiari Malformation Type I: Comparison of Bioinformatic Programs for Untargeted Analysis" (2017). Williams Honors College, Honors Research Projects. 578.
https://ideaexchange.uakron.edu/honors_research_projects/578