Date of Graduation

Spring 2016

Document Type

Honors Research Project

Degree Name

Bachelor of Science

Major

Biology

Research Sponsor

Dr. Rolando Ramirez

First Reader

Dr. Jordan Renna

Second Reader

Kelly Stevanov

Abstract

Four groups of experimental mice are studied in this experiment following intentional exposure to murine norovirus (MNV). Two groups are exposed to the virus at different points in their lives, and the other two are not infected and studied alongside the other groups as controls.

Past research has indicated that B and T immune cells are not essential to MNV resistance. Additionally, antibody production against MNV has shown to be slow as infection progresses. Thus, the expected results from the experiment are that the mice with longer infections of MNV will have larger quantities of IgG than those more recently infected with the virus. Immunological data gathered from these groups is compared to IgG counts from control mice, which are comprised of pathologically clean mice of the same strain as the sentinel mice infected with MNV and the same strain as the colony with innate exposure to MNV.

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