Chemical and Biomolecular Engineering Faculty Research

Title

Green Polymer Chemistry: Precision Synthesis of Novel Multifunctional Poly(Ethylene Glycols) Using Enzymatic Catalysis

Document Type

Article

Publication Date

4-2011

Abstract

This paper gives an overview about enzyme catalysis, and reports the precision synthesis of multifunctional poly(ethylene glycol)s using this green chemistry approach. Specifically, vinyl acrylate was transesterified with tetraethylene glycol (TEG) and a PEG with DPn=23, and then (HO)2–TEG–(OH)2 and (HO)2–PEG–(OH)2 were synthesized by the Michael addition of diethanolamine to the acrylate double bonds. These structures will serve as the core of novel dendrimers designed for drug delivery applications.

Publication Title

European Polymer Journal

Volume

47

Issue

4

First Page

524

Last Page

534