Chemical and Biomolecular Engineering Faculty Research

Title

Drug-eluting Stent Coatings

Document Type

Article

Publication Date

8-2009

Abstract

This paper reviews the development of coronary stents from a polymer scientist's view point, and presents the first results of an interdisciplinary team assembled for the development of new stent systems. Poly(styrene-b-isobutylene-b-styrene) block copolymer (SIBS), a nanostructured thermoplastic elastomer, is used in clinical practice as the drug-eluting polymeric coating on the Taxus coronary stent (trademark of Boston Scientific Co.). Our group has been developing new architectures comprising of arborescent (dendritic) polyisobutylene cores (D_SIBS), which were shown to be as biocompatible as SIBS. ElectroNanospray (Nanocopoeia Inc.™) was used to coat test coupons and coronary stents with selected DSIBS polymers loaded with dexamethasone, a model drug. The surface topology varied from smooth to nanosized particulate coating. This paper will demonstrate how drug release profiles were influenced by both the molecular weight of the polyisobutylene core and spraying conditions of the polymer-drug mixture. Copyright © 2009 John Wiley & Sons, Inc.

Publication Title

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Volume

1

Issue

4

First Page

451

Last Page

462