Chemical and Biomolecular Engineering Faculty Research

Title

Ultralow Fouling Zwitterionic Polymers Grafted from Surfaces Covered with an Initiator via an Adhesive Mussel Mimetic Linkage

Document Type

Article

Publication Date

Fall 2008

Abstract

In this work, nonfouling zwitterionic polymers were grafted via surface-initiated atom transfer radical polymerization (ATRP) from surfaces covered with an adhesive catechol initiator. The catechol initiator was attached to both bare gold and amino-functionalized surfaces, and the nonfouling performances of the resulting polymer brushes were compared. Under optimal conditions, ultralow protein adsorption from both single-protein solutions of fibrinogen and lysozyme and complex media of 10% blood serum and 100% blood plasma/serum was achieved. Furthermore, the 3-day accumulation of Pseudomonas aeruginosa on the treated glass surfaces was studied in situ using a laminar flow chamber. The results showed that these zwitterionic coatings dramatically reduced the biofilm formation of P. aeruginosa as compared to the reference bare glass.

Volume

112

First Page

15269

Last Page

15274