Chemical and Biomolecular Engineering Faculty Research

Title

Strong Resistance of Poly (Ethylene Glycol) Based L-tyrosine Polyurethanes to Protein Adsorption and Cell Adhesion

Document Type

Article

Publication Date

Fall 2012

Abstract

Biofouling that involves protein adsorption, cell and bacteria adhesion, and biofilm formation between a surface and biological entities is a great challenge for biomedical and industry applications. In this work, l-tyrosine-derived polyurethanes (l-polyurethane) with different molecular weights of poly(ethylene glycol) (PEG) were synthesized, characterized and coated on gold surfaces using spin-coating. The non-fouling activity of different l-polyurethane films was evaluated by protein adsorption and cell adhesion. Surface plasmon resonance and cell assay results demonstrate that the PEG content in these l-polyurethanes contributes excellent resistance to protein adsorption and cell attachments. This work provides alternative and effective biomaterials for potential applications in blood-contacting devices. Copyright © 2011 Society of Chemical Industry

Volume

61

First Page

616

Last Page

621